Sunday, October 1
6:00 - 7:00 PM
Registration
7:00 - 9:00
Welcome reception & Dinner Introductory remarks - Larry Matherly
Gerrit Jansen, Ph.D. Bart Kamen Lecture: “Methotrexate in Cancer and Arthritis Treatment: The Best of Two Worlds”
Monday, October 2 - Session 1
SLC Folate Transporters: Structures and Function - Session Chair: I. David Goldman, M.D.
7:30 - 8:15 AM Breakfast/Coffee
8:20 - 8:30
I. David Goldman, M.D. “Introductory Comments”
8:30 - 9:00
I. David Goldman, M.D. “RFC and PCFT: “From Kinetics, Energetics and SCAM to Structures and Return”
9:00 - 9:30
Simon Newstead, Ph.D. “Uncovering the Role of PCFT in Folate and Antifolate Recognition and Transport”
9:30 - 10:00
Andras Fiser, Ph.D. “Mechanistic Insight into Loss of Function and Compensatory Gain of Function Mutations in hPCFT”
10:00 - 10:30
Justin Fedor, Ph.D. “Methotrexate Recognition and Insights into Transport by the Human Reduced Folate Carrier SLC19A1”
10:30 - 11:00 Coffee/Tea Break
Monday, October 2 - Session 2
One-carbon Metabolism - Session Chair: Larry Matherly, Ph.D.
11:00 - 11:30
Joshua Rabinowitz, Ph.D. “1C Metabolism: Lessons from Metabolomics and Isotope Tracing”
11:30 - 12:00 PM
Vidhi Pareek, Ph.D. “The Purinosome Metabolon and Folate Cofactor Utilization for Purine Synthesis”
12:00 - 12:30
Patrick Stover, Ph.D. “Nuclear One-carbon Metabolism and Genome Stability”
12:45 Lunch and Free Time - Scientific Program Resumes at 2:00 pm
Monday, October 2 - Session 3
FR-targeted Immuno-therapeutics - Session Chair: Mariangela Figini, Ph.D.
2:00 - 2:30
Philip Low, Ph.D. “Development of Folate-Targeted Drugs for Treatment of Cancers, Autoimmune, and Infectious Diseases”
2:30 - 3:00
Keith Knudson, Ph.D. “Folate Receptor Targeted Vaccines for the Treatment of Ovarian Cancer”
3:00 - 3:30
Dan Powell, Ph.D. “CAR T cell therapy targeting FR isoforms”
3:30 - 4:00
Tim Ratliff, Ph.D. “Immunotherapy of Prostate Cancer”
4:00 - 4:30 Coffee/Tea Break and Group Photo
4:30 - 5:00
Sophia Karagiannis, Ph.D. “IgE Immunotherapy for Solid Tumors Targeting FRα”
5:00 - 5:30
Amaya Puig-Kroger, Ph.D. “The Macrophage Reprogramming Ability of MTX in Inflammatory Diseases: From Mechanism of Action to Biomarkers”
5:30 - 5:50
John Napoleon, Ph.D. “Reprogramming of Tumor-infiltrating Immune Cells using a Tumor-associated Macrophage Targeted TLR7 Agonist”
6:00 - 7:00 Board Meeting
7:30 Dinner
Tuesday, October 3 - Session 4
Folates and the Central Nervous System - Session Chair: Reina Bendayan, Ph.D.
7:45 - 8:30 AM Breakfast/Coffee
8:30 - 9:00
Reina Bendayan, Ph.D. “Regulatory Mechanisms of Folate Transport Pathways at the Blood-Brain-Barrier”
9:00 - 9:30
Edward Quadros, Ph.D. “Folate Uptake and Distribution in the Brain”
9:30 - 10:00
Richard Finnell, Ph.D. “Embryonic Consequences of Abnormal Folate Transport: From Spina Bifida to Stem Cell Therapeutics”
10:00 - 10:30 Coffee/Tea Break
Tuesday, October 3 - Session 5
One-carbon Metabolism and Folate-based Therapeutics - Session Chair: Larry Matherly, Ph.D.
10:30 - 11:00
Larry Matherly, Ph.D. “Mitochondrial One-Carbon Metabolism-A New Target with Broad-Spectrum Anti-Tumor Potential”
11:00 - 11:15
Aleem Gangjee, Ph.D. “Designed Conformational Promiscuity Provides Tumor Selective Transport and Multitarget Inhibition”
11:15 - 11:35
Charles Dann III, Ph.D. “SHMT2 Structural Biology”
11:35 - 12:05 PM Coffee/Tea Break
12:05 - 12:35
Antonio Di Cristofano, Ph.D. “Synthetic Lethality in One-Carbon Metabolism in Anaplastic Thyroid Cancer”
12:35 - 1:05
Martin Hendrickson, Ph.D. “Development and Mechanism of the MTHFD1/2 Inhibitor TH9619”
1:20 Lunch and Free Time - Scientific Program Resumes at 4:30 pm
Tuesday, October 3 - Session 6
FRα-targeted Chemotherapeutics and Other Agents - Session Chair: Philip Low, Ph.D.
4:30 - 5:00
Andrea Kasinski, Ph.D. “Tales of a Folate-mediated Holistic miRNA Delivery Vehicle”
5:00 - 5:20
Udai Banerji, Ph.D. “Localizing DNA-Damage Response Inhibitors to FRα Expressing Tumors”
5:20 - 5:40
Maria Paola Costi, Ph.D. “Improving Targeting of Dimer Disrupters of Thymidylate Synthase through Folate Receptor Conjugates Engineering”
5:40 - 6:00
Robert Cabrera, Ph.D. “Folate Receptor: Ionic and Iconic Drug Interactions”
6:30 - 7:30 Dinner
7:30 - 9:00 Poster Viewing
Wednesday, October 4 - Session 7
Translational Studies - Session Chair: Frits Peters, Ph.D.
Hotel room check-out prior to breakfast
9:00 - 9:45 AM Breakfast/Coffee
9:45 - 10:00
Frits Peters, Ph.D. “Optimization, Evaluation and Application of Thymidylate Synthase Assayed with a New LC-MS Based Assay”
10:00 - 10:15
Helena Taflin, Ph.D. “Measuring Thymidylate Synthase Inhibition in a Real-life Setting- the Modelle 001 trial”
10:15 - 10:45
Naami Kanarek, Ph.D. “Folate Depletion Induces Erythroid Differentiation”
10:45 - 11:15
Fenghua Zhang, Ph.D. “Targeting Immunosuppressive FRa in the Therapy of Cancer”
11:15 - 11:45
Robert de Jonge, Ph.D. “Novel Approaches to Therapeutic Drug Monitoring of MTX in Cancer and Rheumatoid Arthritis”
11:45 Adjourn
12:00 PM Lunch. The campus is available throughout the afternoon with departure by 5 pm